منابع مشابه
Cardiac Troponin Assays
Troponin: Its Utility in Acute Coronary Syndrome Case Presentation 1: J.P. is an obese 55-year-old male with a history of gastroesophageal reflux disease who presents to the emergency department with substernal chest pain that he attributes to a “large meal.” J.P. is pale and diaphoretic. An ECG shows tachycardia with normal sinus rhythm. J.P.’s troponin levels (decision limit 0.04 g/L) at pres...
متن کاملSensitive cardiac troponin assays: sense and sensibility.
To meet the criteria defined in the universal definition of acute myocardial infarction (AMI), sensitive assays for cardiac troponins I and T have recently been introduced into clinical medicine. Such assays are commonly understood to have a detection limit ,99th percentile of a reference population and a total imprecision at the 99th percentile ≤10%. The analytical performance of these assays,...
متن کاملDegradation of cardiac troponin I in serum complicates comparisons of cardiac troponin I assays.
BACKGROUND Up to a 20-fold variation in serum cardiac troponin I (cTnI) concentration may be observed for a given patient sample with different analytical methods. Because more limited variation is seen for control materials and for purified cTnI, we explored the possibility that cTnI was present in altered forms in serum. METHODS We used four recombinantly engineered cTnI fragments to study ...
متن کاملHigh-sensitivity cardiac troponin assays: isn't it time for equality?
There are abundant data that women who present with acute coronary events are less frequently diagnosed and have worse outcomes than men (1, 2 ). Part of the problem may be that women are less apt to manifest increased biomarkers when they present and perhaps for that reason, often receive less aggressive guidelinemandated care (3, 4 ). It may be that the reason for this is that women have lowe...
متن کاملSerum 99th percentile reference cutoffs for seven cardiac troponin assays.
for ovarian cancer testing. We will continue to post all raw data, the exact methods, and the results of the blinded trial(s) for public scrutiny. These are very important times for biomarker discovery and validation. In keeping with the National Cancer Institute Director’s 2015 challenge, effective biomarkers for early detection, risk stratification, and monitoring can save lives and reduce su...
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ژورنال
عنوان ژورنال: Circulation
سال: 2007
ISSN: 0009-7322,1524-4539
DOI: 10.1161/circulationaha.107.722975